Shǒuzú zhī qíng shì zuì shēnhòu de gǎnqíng zhī yī.
The bond between siblings is one of the deepest forms of affection.
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手足 is literary and somewhat formal. In everyday speech, 兄弟 (brothers) or 兄弟姐妹 (siblings) are more common. 手足 is typically reserved for written language or emotional contexts emphasising closeness.
