Louisville is famous for the Kentucky Derby horse race (held the first Saturday in May), Louisville Slugger baseball bats, bourbon distilleries, and being Muhammad Ali's hometown. Founded in 1778 and named after King Louis XVI of France, who supported the American Revolution.
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Transliteration: 路易斯 (Lùyìsī) = "Louis," the same characters used for King Louis. 维尔 (wéi'ěr) is a standard ending for English place names in -ville. Note the original English is pronounced "LOO-uh-vul," but the Chinese tracks the spelling.