Her sense of guilt was so heavy she couldn't sleep all night.
Tips
usage
Most commonly seen in the compound 负罪感 (fùzuìgǎn, 'sense of guilt'), which is the standard psychological term. As a stand-alone verb it's a literary 'bear guilt / be a guilty party.'
memory
负 = 'to carry on the back, bear (a burden)' + 罪 = 'crime, sin.' Picture guilt as a sack you carry around — that's 负罪 in physical form.