Tā zài shìyè shàng hěn shīyì, juédìng huàn gè fāngxiàng.
He was frustrated in his career and decided to change direction.
Tips
usage
失意 is the opposite of 得意 (déyì, proud/satisfied). It implies a broader life disappointment - not just a single setback but a general sense of unfulfilled ambition.