Tā shì èr shí shìjì zuì wěidà de wùlǐxuéjiā zhīyī.
He is one of the greatest physicists of the 20th century.
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usage
Written with Arabic numerals even in Chinese prose — 20世纪 is more common than 二十世纪 in modern publications. Pronounced 'èrshí shìjì'. Use 上世纪 as a shorter synonym when the 21st-century viewpoint is obvious from context.
