By far the most common use is 沮丧 (dejected, depressed). The 'to thwart' sense is more literary. A separate reading jū appears only in some old place and water names.
The three-drop water radical, the side form of 水. The character began as the name of a river; the 'thwart, dampen' senses developed from a sense of being soaked and bogged down.
