Tā zuòshì de shǒubǐ hěn dà, yī chūshǒu jiùshì jǐ bǎi wàn.
She operates on a grand scale — whenever she makes a move, it's in the millions.
Tips
usage
手笔 has two main uses: (1) referring to someone's personal handwriting or artwork; (2) figuratively describing the scale or boldness of one's actions or spending, e.g. 大手笔 (dà shǒubǐ) means 'a grand gesture' or 'big spending'.