Tā chángjī fùzhòng gōngzuò, shēntǐ zhōngyú kuǎ diào le.
He worked under heavy burden for a long time and his health finally broke down.
Tips
usage
负重 can be literal (carrying physical weight) or figurative (bearing a heavy responsibility or emotional burden). The phrase 负重前行 (fùzhòng qiánxíng, 'to press forward under a heavy load') is a popular inspirational expression.