The structure 积…成… ('accumulate … into …') draws on 《荀子·王制》 彼日积劳. The idiom was fixed in 《东周列国志》 (Ming dynasty, Feng Menglong): 公孙归生积劳成病，卧不能起 - 'Gongsun Guisheng fell ill from accumulated toil and could not rise'.
usage
Respectful and somber - typically used about someone who has sacrificed health for work or family. Not for self-aggrandizing complaints about being tired.
