Wǒmen duì yǔzhòu de qǐyuán réngrán zhī zhī shèn shǎo.
We still know very little about the origin of the universe.
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grammar
知之甚少 follows the classical pattern: 知 (know) + 之 (it/object marker) + 甚 (very/extremely) + 少 (little/few). The 之 refers back to the topic being discussed, often introduced by 对...