何事 (héshì): what matter

Meanings

Nǐ zhǎo wǒ héshì?

What matter do you seek me for?

Bùzhī héshì ràng tā rúcǐ shēngqì.

I don't know what matter made him so angry.

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何事 is literary/classical Chinese. Modern equivalents are 什么事 or 为什么. Common in historical dramas and formal writing.

何 hé

事 shì