From Li Mi's 《
陈情表》 (Chen Qing Biao, 'Memorial of Expressing Feelings'), Jin dynasty:
臣少多疾病,九岁不行。
零丁孤苦,至于成立 - Li Mi describes his sickly, orphaned childhood when petitioning the emperor for leave to care for his grandmother. The phrase has carried that note of pitiful solitude ever since.