After a few too many drinks his speech gets slurred.
Tips
register
Colloquial — literally 'big tongue', the imagined cause of the slurred speech. Not clinical; you wouldn't write it in a medical report (use 口齿不清 kǒuchǐ bù qīng for that). Used both for actual lisps and for drunk-slurred speech.
mistakes
The third character is read in the neutral tone — dàshétou, not dàshétóu.